After figuring out how to animate the flames in the Pearl Harbor scene, this scene became a breeze to do. The flames still could use more chaos to the shape they form but since it is only seen for less than a second, I think this works. If I learn some new trick to deform the flames I can return to refine the scene some more.
This morning I added the smoke to the scene. Surprisingly smoke it rather easy to animate with a fractal noise layer with a soft light blend mode. I am thinking I can animate the rising shape of the smoke with hand drawn animation and use that as a matte for this effect. I might do that in a future scene. In this scene I simply let the smoke fill the upper half of the room.
There are quite a few scenes where this style of smoke will do the trick, so I should be able to animate several scenes a day.