Rebound

Dr. Anthony Fauci, the U.S. government’s top infectious disease expert, caught COVID-19 and experienced a recurrence of symptoms after taking the Pfizer’s oral antiviral medication Paxlovid as a treatment for COVID-19.

Fauci reported that he had initially experienced only mild symptoms upon becoming infected with COVID-19 in mid-June 2022. “When [the symptoms] increased, given my age, I went on Paxlovid for five days and I felt really quite well, really just a bit of (runny nose) and fatigue,” said Fauci, 81.

After finishing his course of Paxlovid, Fauci claimed he tested negative for COVID-19 on antigen tests for three days in a row. But on the fourth day, he again tested positive. He also began to experience worsening symptoms. “It was sort of what people are referring to as a ‘Paxlovid rebound,’” Fauci said. Fauci is currently on another course of Paxlovid, he confirmed.

The phenomenon, known as COVID-19 rebound, has been acknowledged by the Centers for Disease Control and Prevention. In May, the CDC issued an advisory on the potential recurrence of symptoms and possibly a “new positive viral test after having tested negative” within two to eight days of finishing a five-day course of Paxlovid.

Rebound

Complacency Waves

Pfizer CEO Albert Bourla warned Wednesday of “constant waves” of COVID-19 caused by complacency around the virus, politicization of the pandemic, and waning immunity.

Cases are rising in the U.S., and the rate at which people are getting vaccinated is falling. In the week that ended May 22, 2022, the US reported 790,000 new cases, more than three times as many as were reported in the last week of March. Of course these numbers are a fraction of how many are becoming infected since testing sites are closed and people test at home if at all.

People are also growing tired of COVID-19 safety regulations, said Bourla, who was speaking at the World Economic Forum in Davos, Switzerland, where world leaders and members of the business elite are gathered for an annual summit.

“What worries me is the complacency,” Bourla said in Davos, adding that fewer people were wearing masks and that even people who have already been vaccinated were less likely to get booster shots. The consequences will likely be seen in three to six months, he said.

Bourla said Pfizer believed that antiviral drugs would replace vaccines as the key weapon in fighting the coronavirus, at least until shots providing a longer period of immunity are developed. Pfizer is “doubling down” on producing its antiviral pill Paxlovid, he added.